Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15208952 | 0.82 | PARP1 (0.64) | PARP1ALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL27901177 | 0.79 | PARP1 (0.69) | PARP1MAPTALDH1A1SMN1; SMN2RAB9A | |
| Iniparib SCHEMBL242006 | 0.77 | PARP1 (1.00) | PARP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| Iniparib SCHEMBL29354973 | 0.77 | PARP1 (1.00) | PARP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL10954211 | 0.76 | PARP1 (0.74) | PARP1MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27515223 | 0.75 | FLT1 (0.61) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL30995722 | 0.75 | PARP1 (0.72) | PARP1LMNAHCAR3CASP6 | |
| SCHEMBL8629267 | 0.75 | PARP1 (0.72) | PARP1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1766442 | 0.75 | PARP1 (0.72) | PARP1LMNAHCAR3CASP6 | |
| SCHEMBL14934251 | 0.74 | PARP1 (0.57) | PARP1MAPTALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089208-A2 | SULFONAMIDE, SULFAMATE AND SULFAMIDE DERIVATIVES OF ANTI-CANCER AGENTS | STICHTING MAASTRICHT RADIATION ONCOLOGY "MAASTRO-CLINIC" (NL) | 2016-06-09 | — | — | WO | disclosed |