Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856400 | 0.84 | MKNK1 (0.53) | MKNK1MKNK2KIF11AKT1TRPV1 | |
| SCHEMBL30578380 | 0.81 | KDM4E (0.65) | KDM4EALDH1A1KMT2AKIF11TRPV1 | |
| SCHEMBL7662428 | 0.80 | MKNK1 (0.61) | MKNK1MKNK2KDM4EALDH1A1KMT2A | |
| SCHEMBL624877 | 0.80 | DGAT1 (0.58) | MKNK1MKNK2KDM4EALDH1A1KMT2A | |
| SCHEMBL2757253 | 0.79 | MKNK1 (0.59) | MKNK1MKNK2AKT1DHODHPTGS1 | |
| SCHEMBL15730173 | 0.79 | MKNK1 (0.59) | MKNK1MKNK2ALDH1A1DHODHPTGS1 | |
| SCHEMBL30563610 | 0.78 | MKNK1 (0.58) | MKNK1MKNK2ALDH1A1AKT1AKT2 | |
| SCHEMBL2084918 | 0.78 | MKNK1 (0.58) | MKNK1MKNK2ALDH1A1AKT1AKT2 | |
| SCHEMBL5182634 | 0.77 | KDM4E (0.59) | KDM4EALDH1A1KMT2AKIF11AKT1 | |
| SCHEMBL18118551 | 0.77 | GLO1 (0.51) | KDM4EALDH1A1KMT2AKIF11DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | MKNK1 2377/4885MKNK2 1286/4885KDM4E 465/4885 |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | MKNK1 2377/4885MKNK2 1286/4885KDM4E 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.