Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 15/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 9/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780568 | 0.88 | DHODH (0.40) | — | |
| SCHEMBL3871624 | 0.86 | ALK (0.42) | AURKAABL1INSRALKKIT | |
| SCHEMBL3872622 | 0.86 | ALK (0.42) | AURKAABL1INSRALKKIT | |
| SCHEMBL3872625 | 0.86 | ALK (0.42) | AURKAABL1INSRALKKIT | |
| SCHEMBL1779993 | 0.86 | AURKA (0.45) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779963 | 0.84 | IGF1R (0.52) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779339 | 0.84 | INSR (0.45) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779553 | 0.83 | AURKA (0.44) | AURKAABL1BCRINSRALK | |
| SCHEMBL1778772 | 0.83 | INSR (0.47) | AURKAABL1BCRINSRALK | |
| SCHEMBL742121 | 0.82 | AURKA (0.62) | AURKAABL1BCRINSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |