Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 15/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 15/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 10/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781440 | 0.91 | AURKA (0.55) | INSRALKAURKAABL1BCR | |
| SCHEMBL15362150 | 0.91 | ALK (0.43) | INSRALKAURKAABL1IGF1R | |
| SCHEMBL1779553 | 0.88 | AURKA (0.44) | INSRALKAURKAABL1BCR | |
| SCHEMBL1779993 | 0.87 | AURKA (0.45) | INSRALKAURKAABL1BCR | |
| SCHEMBL1779963 | 0.87 | IGF1R (0.52) | INSRALKAURKAABL1BCR | |
| SCHEMBL1780074 | 0.87 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL3865316 | 0.86 | INSR (0.48) | INSRALKAURKAABL1IGF1R | |
| SCHEMBL1778772 | 0.86 | INSR (0.47) | INSRALKAURKAABL1BCR | |
| SCHEMBL1780489 | 0.84 | AURKA (0.42) | INSRALKAURKAABL1BCR | |
| SCHEMBL1780709 | 0.84 | AURKA (0.45) | INSRALKAURKAABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |