Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742320 | 0.96 | AURKA (0.44) | RXFP1MAPTAURKAABL1BCR | |
| SCHEMBL1779700 | 0.89 | AURKA (0.50) | RXFP1NR1H4PPARGPPARAMAPT | |
| SCHEMBL1779927 | 0.89 | RXFP1 (0.49) | RXFP1NR1H4PPARGPPARAAURKA | |
| SCHEMBL1779328 | 0.89 | RXFP1 (0.44) | RXFP1NR1H4PPARGPPARAAURKA | |
| SCHEMBL1780795 | 0.88 | AURKA (0.45) | RXFP1NR1H4PPARGPPARAAURKA | |
| SCHEMBL1780912 | 0.88 | AURKA (0.49) | RXFP1NR1H4PPARGPPARAAURKA | |
| SCHEMBL1778129 | 0.88 | AURKA (0.43) | RXFP1NR1H4PPARGHSD17B10AURKA | |
| SCHEMBL3876663 | 0.87 | GAA (0.53) | RXFP1MAPTGAATSHRMAPK1 | |
| SCHEMBL2416143 | 0.87 | NPC1 (0.43) | RXFP1MAPTGAAMEN1KMT2A | |
| SCHEMBL1778008 | 0.87 | AURKA (0.49) | RXFP1NR1H4PPARGPPARATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |