Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | USP7 | Q93009 | 1/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.50 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12561176 | 0.87 | PLK1 (0.55) | PLK1USP7PIP5K1CPIK3CAPI4KA | |
| SCHEMBL26993981 | 0.84 | HIF1A (0.50) | USP7PIP5K1CPIK3CAPI4KAPI4KB | |
| SCHEMBL17795260 | 0.82 | EGLN1 (0.66) | USP7EGLN1PIP5K1CPIK3CAPI4KA | |
| SCHEMBL18135107 | 0.82 | HIF1A (0.60) | EGLN1PIP5K1CPIK3CAPI4KAPI4KB | |
| SCHEMBL9613265 | 0.82 | ALDH1A1 (0.57) | EGLN1HIF1ANPC1RAB9A | |
| SCHEMBL23512615 | 0.82 | EGLN1 (0.44) | EGLN1HIF1ANPC1RAB9A | |
| SCHEMBL24061022 | 0.81 | PIP5K1C (0.58) | USP7EGLN1PIP5K1CPIK3CAPI4KA | |
| SCHEMBL27772389 | 0.79 | EGLN1 (0.49) | USP7EGLN1HIF1ANPC1RAB9A | |
| SCHEMBL27173825 | 0.79 | KDR (0.76) | KDR | |
| SCHEMBL17806558 | 0.78 | KDR (0.51) | USP7EGLN1PIP5K1CPIK3CAPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | PLK1 2297/4885USP7 3899/4885EGLN1 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.