Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17810131 | 0.85 | APP (0.32) | APPCYP11B1CYP11B2MCHR1NR1H4 | |
| SCHEMBL1500061 | 0.85 | MCHR1 (0.41) | APPCYP11B1CYP11B2MCHR1NR1H4 | |
| SCHEMBL17810219 | 0.83 | PDE10A (0.34) | APPCYP11B1CYP11B2MCHR1NR1H4 | |
| SCHEMBL17810161 | 0.81 | MCHR1 (0.34) | APPCYP11B1CYP11B2MCHR1 | |
| SCHEMBL7998877 | 0.77 | MCHR1 (0.36) | APPCYP11B1CYP11B2MCHR1 | |
| SCHEMBL22363049 | 0.74 | USP7 (0.40) | APPCYP11B1CYP11B2 | |
| SCHEMBL17810209 | 0.73 | PDE10A (0.34) | APPCYP11B1CYP11B2 | |
| SCHEMBL15111001 | 0.72 | APP (0.33) | APPCYP11B1CYP11B2 | |
| SCHEMBL6491442 | 0.72 | ALDH1A1 (0.49) | — | |
| SCHEMBL15110953 | 0.71 | KDM4C (0.34) | APPCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365540-B2 | Benzimidazole derivatives as MCH receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-14 | — | — | US | disclosed |