Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500061 | 0.85 | MCHR1 (0.41) | PDE10AKDM4EAPPMCHR1CYP11B1 | |
| SCHEMBL17810131 | 0.85 | APP (0.32) | ALDH1A1APPMCHR1CYP11B1CYP11B2 | |
| SCHEMBL17810161 | 0.84 | MCHR1 (0.34) | APPMCHR1CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL17810133 | 0.83 | APP (0.35) | APPMCHR1CYP11B1CYP11B2NR1H4 | |
| SCHEMBL16462409 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2NOTUMPOLB | |
| SCHEMBL7998877 | 0.77 | MCHR1 (0.36) | ALDH1A1APPMCHR1CYP11B1CYP11B2 | |
| SCHEMBL15416735 | 0.77 | GAA (0.35) | PDE10AALDH1A1KDM4EAPPRAB9A | |
| SCHEMBL15112575 | 0.75 | CYP11B1 (0.35) | ALDH1A1KDM4EAPPCYP11B1CYP11B2 | |
| SCHEMBL22363049 | 0.74 | USP7 (0.40) | APPCYP11B1CYP11B2 | |
| SCHEMBL4311336 | 0.73 | SMN1; SMN2 (0.45) | ALDH1A1KDM4EMCHR1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365540-B2 | Benzimidazole derivatives as MCH receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-14 | — | — | US | disclosed |