Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESRRG | P62508 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176237 | 0.89 | DGAT1 (0.51) | DGAT1KDRTEKGAANPC1 | |
| SCHEMBL178101 | 0.83 | DGAT1 (0.42) | DGAT1KDRTEKGAAESR1 | |
| SCHEMBL178104 | 0.83 | DGAT1 (0.42) | DGAT1KDRTEKGAAESR1 | |
| SCHEMBL15022157 | 0.82 | DGAT1 (0.41) | DGAT1LOXL2KDRTEKGAA | |
| SCHEMBL15022160 | 0.82 | DGAT1 (0.41) | DGAT1LOXL2KDRTEKGAA | |
| SCHEMBL174941 | 0.81 | DGAT1 (0.46) | DGAT1LOXL2KDRLOXL3NPC1 | |
| SCHEMBL176339 | 0.81 | DGAT1 (0.52) | DGAT1KDRTEKGAANPC1 | |
| SCHEMBL162408 | 0.80 | DGAT1 (0.44) | DGAT1KDRTEKESR1ESRRG | |
| SCHEMBL162409 | 0.80 | DGAT1 (0.44) | DGAT1KDRTEKESR1ESRRG | |
| SCHEMBL160965 | 0.79 | DGAT1 (0.41) | DGAT1KDRTEKGAAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |