Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175407 | 0.91 | DGAT1 (0.47) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL176237 | 0.90 | DGAT1 (0.51) | DGAT1CDK5KDRFLT3KIT | |
| SCHEMBL178251 | 0.89 | NTRK1 (0.45) | DGAT1KDRMEN1KMT2A | |
| SCHEMBL176339 | 0.81 | DGAT1 (0.52) | DGAT1CDK5KDRFLT3KIT | |
| SCHEMBL178102 | 0.81 | DGAT1 (0.41) | DGAT1ERCC5FEN1CDK5KDR | |
| SCHEMBL178118 | 0.80 | DGAT1 (0.47) | DGAT1KDRMEN1KMT2A | |
| SCHEMBL174942 | 0.79 | DGAT1 (0.48) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL15021905 | 0.78 | DGAT1 (0.48) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL175408 | 0.77 | DGAT1 (0.48) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL15021930 | 0.76 | DGAT1 (0.47) | DGAT1CNR1NAMPTERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |