Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 11/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17811776 | 0.84 | S1PR4 (0.38) | S1PR4AAK1 | |
| SCHEMBL17812432 | 0.82 | S1PR4 (0.47) | S1PR4 | |
| SCHEMBL17811774 | 0.82 | — | — | |
| SCHEMBL17815784 | 0.81 | S1PR4 (0.46) | S1PR4 | |
| SCHEMBL17811773 | 0.81 | L3MBTL1 (0.32) | — | |
| SCHEMBL16371814 | 0.73 | MRGPRX4 (0.44) | S1PR4 | |
| SCHEMBL17811811 | 0.72 | PPARA (0.39) | S1PR4 | |
| SCHEMBL17815734 | 0.68 | S1PR4 (0.55) | S1PR4 | |
| SCHEMBL17811819 | 0.68 | PDE2A (0.40) | S1PR4 | |
| SCHEMBL17811800 | 0.68 | SMN1; SMN2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | VERTEX PHARMACEUTICALS INCORPORATED | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | TRPV1, TRPA1, KCNJ2 | S1PR4 945/4885AAK1 457/4885METAP2 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.