Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.42 |
| ▸ | TFEB | P19484 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19732049 | 0.75 | KDM4E (0.51) | KDM4ENFE2L2TFEBKMT2ATLR2 | |
| SCHEMBL15481174 | 0.75 | KDM4E (0.51) | KDM4ENFE2L2TFEBKMT2ATLR2 | |
| SCHEMBL31689790 | 0.74 | NFE2L2 (0.55) | KDM4ENFE2L2TFEBTLR2ERN1 | |
| SCHEMBL31689795 | 0.74 | NFE2L2 (0.55) | KDM4ENFE2L2TFEBTLR2ERN1 | |
| SCHEMBL9689786 | 0.72 | KDM4E (0.68) | KDM4ENFE2L2TFEBMAPTNPC1 | |
| SCHEMBL16831490 | 0.72 | KDM4E (0.68) | KDM4ENFE2L2TFEBMAPTNPC1 | |
| SCHEMBL15481173 | 0.68 | MAPT (0.54) | KDM4ENFE2L2TFEBKMT2AMAPT | |
| SCHEMBL16852753 | 0.68 | KDM4E (0.55) | KDM4ENFE2L2TFEBKMT2AMAPT | |
| SCHEMBL16961832 | 0.67 | TLR2 (0.50) | KDM4ENFE2L2TFEBTLR2ERN1 | |
| SCHEMBL17379744 | 0.65 | NFE2L2 (0.46) | KDM4ENFE2L2TFEBTLR2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016090371-A2 | PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS | An2H Discovery Limited (US) | 2016-06-09 | — | — | WO | disclosed |