Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809151 | 0.87 | TSHR (0.58) | TSHRALDH1A1THRBMAPTFAAH | |
| SCHEMBL759159 | 0.85 | TSHR (0.42) | TSHRALDH1A1THRBNAAAHPGD | |
| SCHEMBL9646938 | 0.84 | TSHR (0.55) | TSHRALDH1A1THRBNAAANPSR1 | |
| SCHEMBL7983922 | 0.84 | ALDH1A1 (0.48) | TSHRALDH1A1THRBSOAT1MAPT | |
| SCHEMBL19456885 | 0.84 | TSHR (0.50) | TSHRALDH1A1THRBSOAT1NAAA | |
| SCHEMBL35720 | 0.84 | — | — | |
| Methyl Alcohol SCHEMBL29084611 | 0.82 | ALDH1A1 (0.50) | TSHRALDH1A1THRBSOAT1MAPT | |
| SCHEMBL8357916 | 0.81 | TSHR (0.58) | TSHRALDH1A1THRBFAAHNPSR1 | |
| SCHEMBL375032 | 0.80 | TSHR (0.57) | TSHRALDH1A1THRBNAAANPSR1 | |
| SCHEMBL196925 | 0.80 | ALDH1A1 (0.45) | TSHRALDH1A1MAPTFAAHNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |