Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16115685 | 0.88 | L3MBTL1 (0.50) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL5913520 | 0.87 | L3MBTL1 (0.69) | L3MBTL1KMT2AHPGDMEN1NPSR1 | |
| SCHEMBL3012179 | 0.85 | L3MBTL1 (0.48) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL17512318 | 0.83 | ALDH1A1 (0.46) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL17512317 | 0.83 | ALDH1A1 (0.46) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL20401009 | 0.82 | L3MBTL1 (0.77) | L3MBTL1KMT2AHPGDMEN1NPSR1 | |
| SCHEMBL2569392 | 0.82 | L3MBTL1 (0.67) | L3MBTL1KMT2AHPGDMEN1NPSR1 | |
| SCHEMBL31509357 | 0.81 | MAPT (0.56) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL1360146 | 0.81 | MAPT (0.56) | L3MBTL1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL3190849 | 0.81 | L3MBTL1 (0.65) | L3MBTL1KMT2AHPGDMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2792674-B1 | IMIDAZOLIDINEDIONE COMPOUNDS AND THEIR USES | HINOVA PHARMACEUTICAL INC (CN) | 2016-05-25 | — | — | EP | disclosed |
| US-9346764-B2 | Imidazolidinedione compounds and their uses | HINOVA PHARMACEUTICALS INC. (CN) | 2016-05-24 | — | — | US | disclosed |
| US-9346764-B2 | Imidazolidinedione compounds and their uses | HINOVA PHARMACEUTICALS INC. (CN) | 2016-05-24 | — | — | US | disclosed |
| US-9346764-B2 | Imidazolidinedione compounds and their uses | HINOVA PHARMACEUTICALS INC. (CN) | 2016-05-24 | — | — | US | disclosed |
| US-9115092-B2 | Substituted quinazoline and pyrido-pyrimidine derivatives | ASANA BIOSCIENCES, LLC (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115092-B2 | Substituted quinazoline and pyrido-pyrimidine derivatives | ASANA BIOSCIENCES, LLC (US) | 2015-08-25 | — | — | US | disclosed |
| US-9115092-B2 | Substituted quinazoline and pyrido-pyrimidine derivatives | ASANA BIOSCIENCES, LLC (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150011547-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ASANA BIOSCIENCES, LLC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011547-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ASANA BIOSCIENCES, LLC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011547-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ASANA BIOSCIENCES, LLC (US) | 2015-01-08 | — | — | US | disclosed |
| US-20120129851-A1 | Substituted Quinazoline and Pyrido-Pyrimidine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| WO-2012058671-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012058671-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| WO-2009112565-A1 | THIAZOLYL-DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | L3MBTL1 777/4885KMT2A 2863/4885HPGD 998/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | L3MBTL1 777/4885KMT2A 2863/4885HPGD 998/4885 |
| US-20150011547-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | MTOR, PIK3CA, PDPK1 | L3MBTL1 3261/4885KMT2A 1584/4885HPGD 1434/4885 |
| US-20120129851-A1 | Substituted Quinazoline and Pyrido-Pyrimidine Derivatives | MTOR, PIK3CA, PDPK1 | L3MBTL1 3261/4885KMT2A 1584/4885HPGD 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.