Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780049 | 0.87 | ALDH1A1 (0.66) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL1779254 | 0.86 | ALDH1A1 (0.61) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL1780301 | 0.86 | TSHR (0.60) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL17838915 | 0.86 | HPGD (0.70) | GAATSHRHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL1781844 | 0.81 | TSHR (0.42) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL1781842 | 0.81 | TSHR (0.42) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL12075332 | 0.81 | TSHR (0.42) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL1781312 | 0.80 | ALDH1A1 (0.52) | GAATSHRRXFP1HPGDSMN1; SMN2 | |
| SCHEMBL10025782 | 0.79 | MAPT (0.59) | GAATSHRHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL1781080 | 0.79 | GAA (0.45) | GAATSHRRXFP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144889-B1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2012-08-29 | — | — | EP | claimed |
| US-8592430-B2 | Quinazolin-oxime derivatives as Hsp90 inhibitors | DAC SLR (IT) | 2013-11-26 | — | — | US | disclosed |
| US-8481459-B2 | Chemical inhibitors of ethylene biosynthesis | ACADEMIA SINICA (TW) | 2013-07-09 | — | — | US | disclosed |
| US-8481459-B2 | Chemical inhibitors of ethylene biosynthesis | ACADEMIA SINICA (TW) | 2013-07-09 | — | — | US | disclosed |
| EP-2144889-B1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2012-08-29 | — | — | EP | disclosed |
| EP-2144889-B1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2012-08-29 | — | — | EP | disclosed |
| US-20120023625-A1 | CHEMICAL INHIBITORS OF ETHYLENE BIOSYNTHESIS | ACADEMIA SINICA (TW) | 2012-01-26 | — | — | US | disclosed |
| US-20120023625-A1 | CHEMICAL INHIBITORS OF ETHYLENE BIOSYNTHESIS | ACADEMIA SINICA (TW) | 2012-01-26 | — | — | US | disclosed |
| US-20110118258-A1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20110118258-A1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2011-05-19 | — | — | US | disclosed |
| US-20110118258-A1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2011-05-19 | — | — | US | disclosed |
| EP-2144889-A2 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC S.r.l. (IT) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008142720-A2 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008142720-A2 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | DAC SRL (IT) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120023625-A1 | CHEMICAL INHIBITORS OF ETHYLENE BIOSYNTHESIS | COASY, ACACB, FDPS | GAA 306/4885TSHR 4240/4885RXFP1 3916/4885 |
| US-20110118258-A1 | QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS | HSP90AB1, HSP90AA1, HSP90B1 | GAA 1626/4885TSHR 1723/4885RXFP1 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.