Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22484223 | 0.81 | HSP90AA1 (0.41) | SSTR4CYP1A2CYP3A4CYP2C19SCN9A | |
| SCHEMBL17811783 | 0.81 | MAPK1 (0.35) | CYP1A2CYP3A4CYP2C19SCN9ASMN1; SMN2 | |
| SCHEMBL15599217 | 0.80 | SSTR4 (0.38) | SSTR4SCN9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL19823762 | 0.80 | KCNJ5 (0.41) | SSTR4CYP2C19SMN1; SMN2KMT2AHPGD | |
| SCHEMBL17428846 | 0.79 | SSTR4 (0.45) | SSTR4CYP1A2CYP3A4CYP2C19SCN9A | |
| SCHEMBL12037985 | 0.78 | SSTR4 (0.39) | SSTR4SMN1; SMN2KMT2AHPGDLMNA | |
| SCHEMBL15599218 | 0.78 | SSTR4 (0.47) | SSTR4CYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL16371790 | 0.77 | MRGPRX4 (0.46) | SCN9ASMN1; SMN2MRGPRX4LMNAMAPK1 | |
| SCHEMBL16372478 | 0.76 | ABL1 (0.39) | SCN9ASMN1; SMN2KMT2AMRGPRX4LMNA | |
| SCHEMBL24599916 | 0.76 | SSTR4 (0.44) | SSTR4CYP1A2CYP3A4CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-03-19 | — | — | US | disclosed |
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | VERTEX PHARMACEUTICALS INCORPORATED | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233191-B2 | Fused piperidine amides as modulators of ion channels | TRPV1, TRPA1, KCNJ2 | SSTR4 2664/4885CYP1A2 3270/4885CYP3A4 3236/4885 |
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | TRPV1, TRPA1, KCNJ2 | SSTR4 2664/4885CYP1A2 3270/4885CYP3A4 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.