Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12037985 | 0.84 | SSTR4 (0.39) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL19823762 | 0.82 | KCNJ5 (0.41) | SSTR4CYP17A1LMNACYP2C9TSHR | |
| SCHEMBL17248006 | 0.81 | NOS3 (0.41) | SSTR4MAPTAPP | |
| SCHEMBL22484223 | 0.80 | HSP90AA1 (0.41) | SSTR4CYP2C9SMN1; SMN2SCN9A | |
| SCHEMBL17815703 | 0.80 | SSTR4 (0.38) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL12037978 | 0.79 | SLC13A5 (0.40) | SSTR4LMNACYP2C9TSHRAPEX1 | |
| SCHEMBL15599248 | 0.79 | CSNK2A1 (0.34) | HTR2AHTR2CCYP17A1LMNACYP2C9 | |
| SCHEMBL15599195 | 0.78 | IDH1 (0.33) | HTR2AHTR2CCYP17A1CYP11B1CYP11B2 | |
| SCHEMBL15599216 | 0.77 | SCN9A (0.44) | SSTR4CYP17A1LMNACYP2C9TSHR | |
| SCHEMBL17428846 | 0.77 | SSTR4 (0.45) | SSTR4SMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970156-B1 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144545-A2 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |