Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,4-Diallyloxybenzene SCHEMBL302448 | 0.88 | CA12 (0.63) | CA12CA1CA9CA2CA7 | |
| SCHEMBL19844431 | 0.83 | CA12 (0.50) | CA12CA1CA9CA2CA7 | |
| SCHEMBL2443600 | 0.82 | CA12 (0.53) | CA12CA1CA9CA2CA7 | |
| SCHEMBL9065504 | 0.81 | CA12 (0.57) | CA12CA1CA9CA2CA7 | |
| SCHEMBL3487338 | 0.81 | CA12 (0.57) | CA12CA1CA9CA2CA7 | |
| SCHEMBL472165 | 0.81 | CA12 (0.57) | CA12CA1CA9CA2CA7 | |
| SCHEMBL910705 | 0.79 | CA12 (0.55) | CA12CA1CA9CA2CA7 | |
| SCHEMBL13066417 | 0.77 | ALDH1A1 (0.50) | NPC1RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL826483 | 0.77 | CA12 (0.53) | CA12CA1CA9CA2CA7 | |
| SCHEMBL9299752 | 0.77 | CA12 (0.53) | CA12CA1CA9CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10974235-B2 | Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation | TRUSTEES OF PRINCETON UNIVERSITY (US) | 2021-04-13 | — | — | US | disclosed |
| US-10543481-B2 | Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation | TRUSTEES OF PRINCETON UNIVESITY (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180037526-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2018-02-08 | — | — | US | disclosed |
| US-20180037526-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2018-02-08 | — | — | US | disclosed |
| WO-2016130549-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-08-18 | — | — | WO | disclosed |
| US-20160158388-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-06-09 | — | — | US | disclosed |
| US-20160158388-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158388-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | AFF2, CLTC, AFF4 | CA12 65/4885CA1 33/4885CA9 45/4885 |
| US-10543481-B2 | Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation | AFF2, CLTC, AFF4 | CA12 65/4885CA1 33/4885CA9 45/4885 |
| US-20180037526-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | AFF2, CLTC, AFF4 | CA12 65/4885CA1 33/4885CA9 45/4885 |
| US-10974235-B2 | Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation | AFF2, CLTC, AFF4 | CA12 65/4885CA1 33/4885CA9 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.