Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16415681 | 0.89 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL510500 | 0.87 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL4131738 | 0.83 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1443663 | 0.83 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL10497693 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1164373 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1958537 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1864244 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1239921 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL1164661 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828393-B2 | Silylalkyloxyaryl compounds and methods for treating cancer | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160159832-A1 | SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159832-A1 | SILYLALKYLOXYARYL COMPOUNDS AND METHODS FOR TREATING CANCER | BCL3, MYLK2, BCL2L13 | ALDH1A1 1626/4885SMN1; SMN2 24/4885LMNA 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.