Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883525 | 0.88 | CRHBP (0.45) | TSHRP2RX7KDM4ESMN1; SMN2 | |
| SCHEMBL2884036 | 0.87 | EGLN1 (0.54) | EGLN1 | |
| SCHEMBL17817948 | 0.86 | GAA (0.44) | GAAPKMTSHRP2RX7EGLN1 | |
| SCHEMBL27743462 | 0.83 | P2RX7 (0.38) | P2RX7EGLN1KDM4ETP53CYP2D6 | |
| SCHEMBL2888968 | 0.77 | CRHBP (0.46) | TSHRP2RX7KDM4ETP53SMN1; SMN2 | |
| SCHEMBL2881083 | 0.77 | CRHBP (0.46) | TSHRP2RX7EGLN1KDM4ETP53 | |
| SCHEMBL2887339 | 0.75 | CYP1A2 (0.47) | GAATSHREGLN1CYP2D6SMN1; SMN2 | |
| SCHEMBL2887944 | 0.74 | EGLN1 (0.57) | EGLN1 | |
| SCHEMBL2886667 | 0.74 | EGLN1 (0.63) | EGLN1 | |
| SCHEMBL2886519 | 0.73 | EGLN1 (0.45) | EGLN1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |