Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 7/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163199 | 0.81 | GAA (0.52) | GAAKDM4EDGAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL159620 | 0.80 | KDM4E (0.49) | GAAKDM4EDGAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL162190 | 0.71 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL160462 | 0.70 | DGAT1 (0.63) | DGAT1 | |
| SCHEMBL2488111 | 0.67 | GAA (0.65) | GAAKDM4EDGAT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14701074 | 0.65 | KDM1A (0.64) | GAAKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL15789220 | 0.65 | KDM1A (0.64) | GAAKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL11621483 | 0.64 | KDM4E (0.56) | GAAKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14662671 | 0.64 | KDM4E (0.51) | GAAKDM4ESMN1; SMN2ALDH1A1POLB | |
| SCHEMBL162444 | 0.63 | TUBB4A (0.55) | GAAKDM4EDGAT1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |