Bromide

Bromide

SCHEMBL17818164

[Br-].c1ccc2cc3c(ccc4cccc([P+](c5cccc6ccc7cc8ccccc8cc7c56)(c5cccc6ccc7cc8ccccc8cc7c56)c5cccc6ccc7cc8ccccc8cc7c56)c43)cc2c1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.46
CYP1A2 P05177 4/20 0.46
ERBB2 P04626 1/20 0.46
FYN P06241 1/20 0.46
MAOA P21397 1/20 0.46
AHR P35869 1/20 0.46
ALDH1A1 P00352 12/20 0.40
HSD17B10 Q99714 10/20 0.40
HPGD P15428 6/20 0.40
HIF1A Q16665 4/20 0.40
CYP1B1 Q16678 2/20 0.40
THRB P10828 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GAA P10253 2/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TSHR P16473 6/20 0.38
CASP1 P29466 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4847644 0.79 ALDH1A1 (0.55) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL4852538 0.79 CYP1A2 (0.60) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL4852657 0.77 ALDH1A1 (0.52) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL5897040 0.76 CYP1A2 (0.48) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL11701192 0.75 ALDH1A1 (0.60) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL598711 0.73 HSD17B10 (0.61) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL587397 0.73 CYP1A2 (0.65) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL4846917 0.73 HSD17B10 (0.61) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL2936549 0.72 CYP1A2 (0.48) CYP1A2ERBB2FYNMAOAACHE
SCHEMBL312508 0.72 CYP1A2 (0.48) CYP1A2ERBB2FYNMAOAACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11549134-B2 Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same KIKKOMAN CORPORATION (JP) 2023-01-10 US disclosed
EP-3760717-A1 AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HBA1C USING THE SAME Kikkoman Corporation (JP) 2021-01-06 EP disclosed
EP-3031914-B1 MODIFIED AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HBA1C USING THE SAME KIKKOMAN CORP (JP) 2020-12-23 EP disclosed
US-20200263228-A1 MODIFIED AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING THE SAME KIKKOMAN CORPORATION (JP) 2020-08-20 US disclosed
US-10619183-B2 Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same KIKKOMAN CORPORATION (JP) 2020-04-14 US disclosed
US-20160186232-A1 MODIFIED AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING THE SAME KIKKOMAN CORPORATION (JP) 2016-06-30 US disclosed
EP-3031914-A1 MODIFIED AMADORIASE AND METHOD FOR PRODUCING SAME, AGENT FOR IMPROVING SURFACTANT-RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING SAME Kikkoman Corporation (JP) 2016-06-15 EP disclosed