Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | IDE | P14735 | 2/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octanedioate SCHEMBL6037701 | 0.98 | TSHR (0.43) | LMNATDP1TSHRNFKB1PMP22 | |
| Glutarate SCHEMBL28187765 | 0.96 | SLC22A6 (0.41) | LMNATDP1TSHRNFKB1PMP22 | |
| Succinic Acid SCHEMBL28474102 | 0.92 | ITGB1 (0.39) | LMNATDP1TSHRABL1IDE | |
| Hexanoate SCHEMBL8822104 | 0.92 | AKR1B1 (0.50) | LMNATDP1TSHRPPARGSLC22A6 | |
| Glutarate SCHEMBL25424321 | 0.91 | CAMK2A (0.38) | LMNATDP1TSHRNFKB1PMP22 | |
| Butyric Acid SCHEMBL9430625 | 0.86 | FFAR3 (0.45) | LMNATDP1TSHRPPARGITGB3 | |
| SCHEMBL28691314 | 0.84 | PTGS1 (0.61) | LMNAMEN1PKMMAPK1KMT2A | |
| SCHEMBL16653758 | 0.83 | HDAC4 (0.36) | TDP1TSHRABL1IDERIN1 | |
| SCHEMBL28269976 | 0.83 | PTGS1 (0.64) | LMNAMEN1PKMMAPK1KMT2A | |
| Chloroacetic Acid SCHEMBL23933671 | 0.83 | TSHR (0.39) | TDP1TSHRITGB3ITGB2ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3717498-A1 | VACCINE AGAINSTKLEBSIELLA PNEUMONIAE | Vaxxilon AG (CH) | 2020-10-07 | — | — | EP | disclosed |
| EP-3230297-A1 | VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 4 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016091399-A1 | VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 4 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-06-16 | — | — | WO | disclosed |