SCHEMBL17823112

SCHEMBL17823112

COC(=O)c1cc(CCNC(=O)C(F)(F)F)ccc1F

nearest known ligand 0.57

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.43
MTNR1B P49286 3/20 0.43
NQO2 P16083 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9786087 0.86 CA12 (0.50)
SCHEMBL20894801 0.85 NPC1 (0.44)
SCHEMBL19026301 0.82 CA1 (0.45) NQO2
SCHEMBL3005286 0.79 MGLL (0.56) MTNR1AMTNR1B
SCHEMBL4453621 0.79 TSHR (0.51)
SCHEMBL15722128 0.79 ALDH1A1 (0.47)
SCHEMBL19643323 0.78 IDO1 (0.44)
SCHEMBL14991977 0.78 CNR2 (0.47)
SCHEMBL6618508 0.77 ALDH1A1 (0.46)
SCHEMBL1968355 0.77 CA12 (0.66)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240199745-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES ABBVIE INC (US) 2024-06-20 US disclosed
EP-3888689-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES AbbVie Inc. (US) 2021-10-06 EP disclosed
EP-3735990-A1 ANTIBODY DRUG CONJUGATES WITH CELL PERMEABLE BCL-XL INHIBITORS Abbvie Inc. (US) 2020-11-11 EP disclosed
US-20200246323-A1 Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors ABBVIE INC. (US) 2020-08-06 US disclosed
EP-3229844-B1 ANTIBODY DRUG CONJUGATES WITH CELL PERMEABLE BCL-XL INHIBITORS ABBVIE INC (US) 2020-03-04 EP disclosed
US-20190153107-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES ABBVIE INC. (US) 2019-05-23 US disclosed
EP-3468598-A1 ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES AbbVie Inc. (US) 2019-04-17 EP disclosed
EP-3468993-A1 ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES AbbVie Inc. (US) 2019-04-17 EP disclosed
WO-2017214456-A1 ANTI-CD98 ANTIBODIES AND ANTIBODY DRUG CONJUGATES ABBVIE INC. (US) 2017-12-14 WO disclosed
EP-3229844-A1 ANTIBODY DRUG CONJUGATES WITH CELL PERMEABLE BCL-XL INHIBITORS AbbVie Inc. (US) 2017-10-18 EP disclosed
US-20170182179-A1 Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors ABBVIE INC. (US) 2017-06-29 US disclosed
WO-2016094505-A1 ANTIBODY DRUG CONJUGATES WITH CELL PERMEABLE BCL-XL INHIBITORS ABBVIE INC. (US) 2016-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199745-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES EGFR, ERBB2, ERBB3 MTNR1A 3522/4885MTNR1B 3931/4885NQO2 1928/4885
US-20170182179-A1 Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors BCL2, BCL2L10, BAX MTNR1A 3819/4885MTNR1B 3925/4885NQO2 802/4885
US-20190153107-A1 ANTI-EGFR ANTIBODY DRUG CONJUGATES EGFR, ERBB2, ERBB3 MTNR1A 3522/4885MTNR1B 3931/4885NQO2 1928/4885
US-20200246323-A1 Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors BCL2, BCL2L10, BAX MTNR1A 3819/4885MTNR1B 3925/4885NQO2 802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.