Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA1 | P00915 | 9/20 | 0.49 |
| ▸ | CA12 | O43570 | 6/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PNMT | P11086 | 6/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238863 | 0.68 | CA1 (0.81) | CA2CA1CA12CA9PNMT | |
| SCHEMBL29710882 | 0.68 | CA1 (0.81) | CA2CA1CA12CA9PNMT | |
| SCHEMBL2710652 | 0.68 | CA2 (0.41) | CA2CA1CA12CA9PNMT | |
| SCHEMBL29902411 | 0.67 | MEN1 (0.63) | CA2CA1CA12CA9PNMT | |
| SCHEMBL689168 | 0.67 | GAA (0.60) | CA2CA1CA12CA9 | |
| SCHEMBL15009998 | 0.67 | CA1 (0.51) | CA2CA1CA12CA9PNMT | |
| SCHEMBL17350895 | 0.67 | CA1 (0.57) | CA2CA1CA12CA9PNMT | |
| SCHEMBL28218357 | 0.66 | KMT2A (0.61) | CA2CA1CA12CA9PNMT | |
| SCHEMBL31236090 | 0.66 | CA2 (0.50) | CA2CA1CA12CA9CA7 | |
| SCHEMBL6955385 | 0.66 | PNMT (0.81) | CA2CA1CA12CA9PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |