Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HEXA | P06865 | 4/20 | 0.48 |
| ▸ | HEXB | P07686 | 4/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17824939 | 0.79 | PARG (1.00) | PARG | |
| SCHEMBL4094368 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL117049 | 0.69 | CYP1B1 (1.00) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL10262751 | 0.69 | CYP1B1 (0.71) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL5594225 | 0.68 | NPSR1 (1.00) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL8913973 | 0.67 | MEN1 (0.54) | ALDH1A1MAPTSMN1; SMN2RECQLCYP1A2 | |
| SCHEMBL1101932 | 0.66 | CYP1B1 (0.73) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL29486056 | 0.66 | CYP1B1 (0.73) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL28737148 | 0.66 | UBE2N (0.82) | KDM4EALDH1A1CYP1B1NPSR1MAPT | |
| SCHEMBL4095117 | 0.66 | ALDH1A1 (0.77) | KDM4EALDH1A1CYP1B1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |