Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825247 | 0.80 | PARG (0.53) | PARG | |
| SCHEMBL17845654 | 0.76 | PARG (0.45) | PARG | |
| SCHEMBL17825422 | 0.69 | PARG (0.39) | PARG | |
| SCHEMBL17832079 | 0.66 | PARG (0.79) | PARG | |
| SCHEMBL17824813 | 0.66 | ALDH1A1 (0.58) | PARG | |
| SCHEMBL17825243 | 0.66 | PARG (0.67) | PARG | |
| SCHEMBL28533960 | 0.66 | PARG (0.51) | PARG | |
| SCHEMBL28531567 | 0.62 | PARG (0.57) | PARG | |
| SCHEMBL28176791 | 0.57 | LMNA (0.39) | PARG | |
| SCHEMBL17825266 | 0.56 | PARG (1.00) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |