Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | AGER | Q15109 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16603958 | 0.83 | AGER (0.71) | HPGDPRMT5ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16603956 | 0.81 | BACE1 (0.67) | HPGDPRMT5ALDH1A1MAPTLMNA | |
| SCHEMBL11520647 | 0.81 | PRMT5 (0.59) | PRMT5ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8534976 | 0.80 | PRMT5 (0.55) | PRMT5ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL16603964 | 0.80 | BACE1 (0.69) | HPGDPRMT5ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16603973 | 0.78 | SMN1; SMN2 (0.71) | HPGDPRMT5ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11693545 | 0.78 | PRMT5 (0.56) | PRMT5ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL12742354 | 0.77 | KMT2A (0.60) | HPGDPRMT5ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11506155 | 0.77 | PRMT5 (0.54) | PRMT5ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL7149272 | 0.76 | KMT2A (0.66) | HPGDPRMT5ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | NEW YORK UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9364472-B2 | Amino, Amido and heterocyclic compounds as modulators of RAGE activity and uses thereof | NEW YORK UNIVERSITY (US) | 2016-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263125-A1 | AMINO, AMIDO AND HETEROCYCLIC COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF | AGER, IAPP, GPR119 | HPGD 746/4885PRMT5 342/4885ALDH1A1 3152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.