Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14823910 | 0.83 | POLB (0.40) | POLBRIPK1CYP2D6TAAR1LMNA | |
| SCHEMBL24486721 | 0.79 | TAAR1 (0.43) | POLBTAAR1SLC6A2 | |
| SCHEMBL26229171 | 0.76 | TP53 (0.35) | RIPK1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20460278 | 0.75 | SLC6A2 (0.44) | ALDH1A1CYP2C19CYP2D6HIF1ATAAR1 | |
| SCHEMBL24240340 | 0.75 | TSHR (0.36) | POLBRIPK1MEN1KMT2ATSHR | |
| SCHEMBL24230507 | 0.72 | RIPK1 (0.42) | POLBRIPK1TAAR1SLC6A2 | |
| SCHEMBL20219018 | 0.72 | POLB (0.33) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20460255 | 0.72 | — | — | |
| SCHEMBL14583067 | 0.71 | HSD11B1 (0.35) | ALDH1A1MEN1KMT2AGAAPKM | |
| SCHEMBL20777014 | 0.71 | RIPK1 (0.34) | RIPK1ALDH1A1GAACYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365597-B2 | Mitochondria-targeted inhibitors of cytochrome c peroxidase for protection from apoptosis | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2016-06-14 | — | — | US | disclosed |