Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | HPD | P32754 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279270 | 0.88 | ALDH1A1 (0.52) | KDM4EL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL6840348 | 0.84 | KMT2A (0.53) | AURKAKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL702708 | 0.82 | AURKA (0.54) | AURKAKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL4947302 | 0.81 | HSP90AA1 (0.56) | KDM4EL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL6840347 | 0.81 | AURKA (0.64) | AURKAKDM4EL3MBTL1POLBMEN1 | |
| SCHEMBL6840233 | 0.78 | AURKA (0.52) | AURKAKDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL4922308 | 0.78 | L3MBTL1 (0.48) | KDM4EL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL25380366 | 0.76 | PPARG (0.47) | AURKAL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL30561348 | 0.76 | PPARG (0.47) | AURKAL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL29703089 | 0.75 | AURKA (0.50) | AURKAKDM4EL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358202-B1 | BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2016-06-15 | — | — | EP | disclosed |