Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591849 | 0.83 | MAP4K4 (0.49) | MAP4K4SCN10ASCN2AGRIN1GRIN2B | |
| SCHEMBL16135138 | 0.81 | GPR55 (0.59) | PRMT5WDR77SCN10AGPR55CHRNB4 | |
| SCHEMBL4591262 | 0.81 | CYP11B1 (0.53) | MAP4K4PRMT5WDR77SCN10ASCN2A | |
| SCHEMBL9413197 | 0.81 | MAP4K4 (0.51) | MAP4K4PRMT5WDR77SCN10ASCN2A | |
| SCHEMBL10271979 | 0.81 | CYP11B1 (0.54) | PRMT5WDR77GPR55MKNK1MKNK2 | |
| SCHEMBL26614623 | 0.81 | CYP2A6 (0.50) | PRMT5WDR77GPR55BACE1KCNH2 | |
| SCHEMBL13177775 | 0.80 | CYP1A1 (0.45) | PRMT5WDR77GPR55BACE1KCNH2 | |
| SCHEMBL13990892 | 0.77 | CYP2A6 (0.53) | PRMT5WDR77SCN10AKCNH2CYP11B1 | |
| SCHEMBL12525157 | 0.76 | PRMT5 (0.41) | PRMT5WDR77GPR55BACE1KCNH2 | |
| SCHEMBL805059 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379535-B1 | 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2016-06-15 | — | — | EP | disclosed |