Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.54 |
| ▸ | FDPS | P14324 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16118323 | 0.85 | CYP2A6 (0.56) | CYP11B1CYP11B2TP53MKNK1MKNK2 | |
| SCHEMBL16135139 | 0.85 | CYP11B1 (0.51) | CYP11B1CYP11B2FDPSATMMKNK1 | |
| SCHEMBL13177775 | 0.83 | CYP1A1 (0.45) | CYP11B1CYP11B2FDPSPRMT5WDR77 | |
| SCHEMBL18174623 | 0.81 | PRMT5 (0.46) | CYP11B1CYP11B2FDPSMKNK1MKNK2 | |
| SCHEMBL17826987 | 0.81 | MAP4K4 (0.47) | CYP11B1CYP11B2MKNK1MKNK2PRMT5 | |
| SCHEMBL16135138 | 0.81 | GPR55 (0.59) | CYP11B1CYP11B2PRMT5WDR77GPR55 | |
| SCHEMBL11625059 | 0.80 | MEN1 (0.54) | CYP11B1CYP11B2MKNK1MKNK2PRMT5 | |
| SCHEMBL20178543 | 0.80 | CTSS (0.43) | CYP11B1CYP11B2PRMT5WDR77BCL2 | |
| SCHEMBL5021664 | 0.80 | FDPS (0.57) | CYP11B1CYP11B2FDPSATMMKNK1 | |
| SCHEMBL2646363 | 0.80 | CYP11B1 (0.54) | CYP11B1CYP11B2FDPSATMMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3301097-B1 | [1]BENZOTHIENO[3',2':4,5]IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN ORGANIC LIGHT-EMITTING DEVICES (OLEDS) | SAMSUNG DISPLAY CO LTD (KR) | 2020-08-19 | — | — | EP | disclosed |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-31 | — | — | US | disclosed |
| US-9205087-B1 | 6-Piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-08 | — | — | US | disclosed |
| US-9199969-B1 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-12-01 | — | — | US | disclosed |
| US-9145388-B2 | 6-piperazinyl-3,4-dihydroquinazolin-2(1H)-ones | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-09-29 | — | — | US | disclosed |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-08-20 | — | — | US | disclosed |
| US-9073900-B2 | Dihydroquinone derivatives of piperidine and piperazine | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2015-07-07 | — | — | US | disclosed |
| US-20150094467-A1 | DIHYDROQUINONE DERIVATIVES OF PIPERIDINE AND PIPERAZINE | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2015-04-02 | — | — | US | disclosed |
| US-8916704-B1 | Dihydroquinone derivatives of piperidine and piperazine | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2014-12-23 | — | — | US | disclosed |
| US-8901304-B1 | Benzo[D]imidazole derivatives of piperidine and piperazine | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2014-12-02 | — | — | US | disclosed |
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (SA) | 2014-10-02 | — | — | US | disclosed |
| US-8309577-B2 | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120035178-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | BRISTOL-MYERS SQUIBB COMPANY | 2012-02-09 | — | — | US | disclosed |
| US-7741281-B2 | Hepatitis C virus inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-22 | — | — | US | disclosed |
| US-20100099684-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-22 | — | — | US | disclosed |
| US-20080312435-A1 | Imine Compound | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-18 | — | — | US | disclosed |
| US-20070099825-A1 | ethyl 2-(biphenyl-4-yl)-6-(tert-butoxycarbonylamino)-2-methoxy-8-(2-nitrophenylsulfonyl)-5,16-dioxo-1,2,3,5,6,7,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[n]pyrrolo[2,1-c][1,4,8]triazacyclopentadecine-14a-carboxylate; viricide; synergistic with other active ingredients | BRISTOL-MYERS SQUIBB COMPANY | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099684-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | CHRNA7, CHRNA5, CHRNA6 | CYP11B1 2659/4885CYP11B2 2940/4885FDPS 3273/4885 |
| US-20080312435-A1 | Imine Compound | CNR1, CNR2, HRH4 | CYP11B1 1440/4885CYP11B2 1428/4885FDPS 4026/4885 |
| US-20120035178-A1 | Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands | CHRNA7, CHRNA5, CHRNA6 | CYP11B1 2659/4885CYP11B2 2940/4885FDPS 3273/4885 |
| US-20070099825-A1 | ethyl 2-(biphenyl-4-yl)-6-(tert-butoxycarbonylamino)-2-methoxy-8-(2-nitrophenylsulfonyl)-5,16-dioxo-1,2,3,5,6,7,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[n]pyrrolo[2,1-c][1,4,8]triazacyclopentadecine-14a-carboxylate; viricide; synergistic with other active ingredients | TERT, VIP, YWHAZ | CYP11B1 3483/4885CYP11B2 3849/4885FDPS 4117/4885 |
| US-20140296528-A1 | 4-ARYL-1-(BIARYLMETHYLENE) PIPERIDINE COMPOUNDS | HTR2C, HTR3C, HTR1D | CYP11B1 1826/4885CYP11B2 1704/4885FDPS 4082/4885 |
| US-20150094467-A1 | DIHYDROQUINONE DERIVATIVES OF PIPERIDINE AND PIPERAZINE | HTR2C, HTR5A, HTR2A | CYP11B1 1956/4885CYP11B2 1344/4885FDPS 3996/4885 |
| US-20150374695-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | HTR2C, HTR2A, HTR1B | CYP11B1 2010/4885CYP11B2 910/4885FDPS 4520/4885 |
| US-20150232448-A1 | 6-PIPERAZINYL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONES | HTR2C, HTR2A, HTR1B | CYP11B1 2010/4885CYP11B2 910/4885FDPS 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.