Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 3/20 | 0.58 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17831344 | 0.84 | MAPT (0.51) | RAB9AMAPTSMN1; SMN2BACE1HPGD | |
| SCHEMBL16245709 | 0.84 | RAB9A (0.51) | PIN1RAB9AMAPTSMN1; SMN2BACE1 | |
| SCHEMBL18869082 | 0.83 | RAB9A (0.49) | PIN1RAB9AMAPTSMN1; SMN2EGFR | |
| SCHEMBL16245606 | 0.80 | PIN1 (0.64) | PIN1GSK3BAURKAGSK3ARAB9A | |
| SCHEMBL16012272 | 0.79 | PIN1 (0.62) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL18869403 | 0.78 | PIN1 (0.59) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL16012720 | 0.77 | PIN1 (0.58) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL16014941 | 0.77 | PIN1 (0.67) | PIN1GSK3BAURKAGSK3ARAB9A | |
| SCHEMBL3976795 | 0.75 | PIN1 (1.00) | PIN1GSK3BAURKAGSK3AMAPT | |
| SCHEMBL15145623 | 0.75 | PIN1 (0.70) | PIN1GSK3BAURKAGSK3ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | PIN1 1347/4885GSK3B 482/4885AURKA 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.