Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 7/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17821168 | 0.86 | EIF2AK4 (0.50) | JAK3BTKEIF2AK4JAK2HDAC6 | |
| SCHEMBL17827728 | 0.82 | JAK3 (0.36) | JAK3BTKHDAC3HDAC8NCOR2 | |
| SCHEMBL17827732 | 0.82 | EIF2AK4 (0.35) | JAK3HDAC3HDAC8EIF2AK4JAK2 | |
| SCHEMBL17821175 | 0.74 | EIF2AK4 (0.56) | JAK3BTKHDAC3HDAC8EIF2AK4 | |
| SCHEMBL17827727 | 0.74 | STK17B (0.41) | CCNCCDK8ALDH1A1BRD4STK17B | |
| SCHEMBL16245534 | 0.71 | GSK3A (0.57) | JAK3BTKHDAC3HDAC8EIF2AK4 | |
| SCHEMBL16246069 | 0.70 | EIF2AK4 (0.51) | JAK3EIF2AK4ALDH1A1JAK2HDAC6 | |
| SCHEMBL16264861 | 0.69 | EIF2AK4 (0.55) | JAK3BTKHDAC3HDAC8EIF2AK4 | |
| SCHEMBL17821176 | 0.69 | EIF2AK4 (0.55) | JAK3BTKHDAC3HDAC8EIF2AK4 | |
| SCHEMBL18869225 | 0.69 | EIF2AK4 (0.51) | JAK3BTKEIF2AK4JAK2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | JAK3 747/4885BTK 269/4885CCNC 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.