Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LGMN | Q99538 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911928 | 0.92 | MAPT (0.43) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL12862276 | 0.92 | MAPT (0.43) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL17264109 | 0.86 | MAPT (0.50) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL310055 | 0.85 | SUV39H2 (0.45) | ALDH1A1HSD17B10ALKEGFRAURKA | |
| SCHEMBL29661369 | 0.85 | SUV39H2 (0.45) | ALDH1A1HSD17B10ALKEGFRAURKA | |
| SCHEMBL15358735 | 0.84 | MAPT (0.58) | MAPTALDH1A1KDM4EMEN1POLB | |
| Hydrochloric Acid SCHEMBL29367159 | 0.84 | SUV39H2 (0.44) | ALDH1A1HSD17B10ALKEGFRAURKA | |
| SCHEMBL13906238 | 0.84 | LGMN (0.49) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL1911970 | 0.82 | MAPT (0.59) | MAPTALDH1A1KDM4EMEN1POLB | |
| SCHEMBL1912008 | 0.82 | ALK (0.43) | LGMNALKEGFRAURKAINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3372594-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | HUMANWELL HEALTHCARE GROUP CO LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| EP-3372594-B1 | PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER | HUMANWELL HEALTHCARE GROUP CO LTD (CN) | 2021-07-21 | — | — | EP | disclosed |
| US-10695347-B2 | Pyrimidine derivative and use thereof | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-06-30 | — | — | US | disclosed |
| US-10695347-B2 | Pyrimidine derivative and use thereof | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2020-06-30 | — | — | US | disclosed |
| US-20180338973-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC. (CN) | 2018-11-29 | — | — | US | disclosed |
| EP-3372594-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | Humanwell Healthcare (Group) Co., Ltd. (CN) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076355-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | 湖北生物医药产业技术研究院有限公司 | 2017-05-11 | — | — | WO | disclosed |
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180338973-A1 | PYRIMIDINE DERIVATIVE AND USE THEREOF | ALK, DPYD, TYMP | MAPT 3032/4885ALDH1A1 252/4885KDM4E 1026/4885 |
| US-10695347-B2 | Pyrimidine derivative and use thereof | ALK, DPYD, TYMP | MAPT 3032/4885ALDH1A1 252/4885KDM4E 1026/4885 |
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | MAPT 663/4885ALDH1A1 2972/4885KDM4E 4543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.