SCHEMBL17833254

SCHEMBL17833254

COC(=O)Nc1ccc(C(=O)CN2C(=O)C(=O)N(Cc3ccccc3)C2=O)cc1

nearest known ligand 0.68

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.68
ALDH1A1 P00352 5/20 0.60
KMT2A Q03164 4/20 0.52
RAB9A P51151 3/20 0.51
LMNA P02545 3/20 0.48
NPC1 O15118 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
PTPN1 P18031 1/20 0.45
MEN1 O00255 2/20 0.44
ITGA4 P13612 1/20 0.44
ITGB7 P26010 1/20 0.44
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20673207 0.88 MAPT (0.71) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL23440095 0.86 ALDH1A1 (0.69) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL20277547 0.85 MAPT (0.74) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL17822176 0.82 MAPT (0.81) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL20282637 0.81 MAPT (0.68) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL17833255 0.80 MAPT (0.78) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL20282822 0.80 ALDH1A1 (0.52) MAPTALDH1A1KMT2ARAB9ANPC1
SCHEMBL17833116 0.79 MAPT (0.76) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL17835171 0.79 MAPT (0.76) MAPTALDH1A1KMT2ARAB9ALMNA
SCHEMBL17833180 0.77 MAPT (0.73) MAPTALDH1A1KMT2ARAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11185100-B2 Methods for modulating taste receptors MARS, INCORPORATED (US) 2021-11-30 US disclosed
US-20190021380-A1 FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME MARS, INCORPORATED (US) 2019-01-24 US disclosed
US-20180168208-A1 FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME MARS, INCORPORATED (US) 2018-06-21 US disclosed
WO-2016094682-A2 FLAVOR COMPOSITIONS AND PET FOOD PRODUCTS CONTAINING THE SAME MARS, INCORPORATED (US) 2016-06-16 WO disclosed