Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277629 | 1.00 | APEX1 (0.59) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL17277149 | 0.90 | APEX1 (0.44) | APEX1 | |
| SCHEMBL17689294 | 0.83 | APEX1 (0.45) | APEX1 | |
| SCHEMBL17277627 | 0.79 | APEX1 (0.72) | APEX1MAPTTDP1ALDH1A1THRB | |
| Apx-3330 SCHEMBL3758716 | 0.75 | APEX1 (1.00) | APEX1MAPTTDP1ALDH1A1THRB | |
| Apx-3330 SCHEMBL3758719 | 0.75 | APEX1 (1.00) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL15705626 | 0.74 | APEX1 (0.70) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL17689687 | 0.73 | APEX1 (0.72) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL15711340 | 0.72 | APEX1 (1.00) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL17277628 | 0.72 | APEX1 (1.00) | APEX1MAPTTDP1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11160770-B2 | Compounds, compositions and methods for treating oxidative DNA damage disorders | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2021-11-02 | — | — | US | disclosed |
| US-20200215001-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OXIDATIVE DNA DAMAGE DISORDERS | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-07-09 | — | — | US | disclosed |
| US-20170304222-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | INDIANA UNIV AND RES TECH CORP (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170304222-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | INDIANA UNIV AND RES TECH CORP (US) | 2017-10-26 | — | — | US | disclosed |
| US-20160166521-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | INDIANA UNIVERSITY AND RES TECHNOLOGY CORP (US) | 2016-06-16 | — | — | US | disclosed |
| US-20160166521-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | INDIANA UNIVERSITY AND RES TECHNOLOGY CORP (US) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200215001-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OXIDATIVE DNA DAMAGE DISORDERS | OGG1, UNG, ERCC4 | APEX1 12/4885MAPT 2382/4885TDP1 40/4885 |
| US-20170304222-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | OGG1, UNG, ERCC4 | APEX1 12/4885MAPT 2382/4885TDP1 40/4885 |
| US-20160166521-A1 | Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders | OGG1, UNG, ERCC4 | APEX1 12/4885MAPT 2468/4885TDP1 38/4885 |
| US-11160770-B2 | Compounds, compositions and methods for treating oxidative DNA damage disorders | OGG1, UNG, ERCC4 | APEX1 12/4885MAPT 2382/4885TDP1 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.