Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238639 | 0.86 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EPOLBMAPT | |
| SCHEMBL14180631 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HSD17B10KDM4EPOLBLMNA | |
| SCHEMBL17427515 | 0.79 | ALDH1A1 (0.40) | ALDH1A1HSD17B10KDM4EPOLBLMNA | |
| SCHEMBL29441612 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EPOLBMEN1 | |
| SCHEMBL11213802 | 0.77 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EPOLBMEN1 | |
| SCHEMBL29122850 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HSD17B10KDM4ELMNAMEN1 | |
| SCHEMBL2631833 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4EPOLBLMNA | |
| SCHEMBL21268024 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HSD17B10KDM4EPOLBLMNA | |
| SCHEMBL14950486 | 0.72 | POLB (0.56) | ALDH1A1HSD17B10KDM4EPOLBLMNA | |
| SCHEMBL10310217 | 0.72 | POLB (0.56) | ALDH1A1HSD17B10KDM4EPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2824098-B1 | Method for the preparation of 4-[3-(4-cyclopropanecarbonyl- piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one | KUDOS PHARM LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| WO-2025065057-A1 | METHODS OF MINIMISING EFFECTS OF RADIATION EXPOSURE | THE UNIVERSITY OF ADELAIDE (AU) | 2025-04-03 | — | — | WO | disclosed |
| CN-118359545-A | Preparation method of Olaparib monohydrate | 杭州中美华东制药有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-116143700-B | Phthalazinone compound, and preparation method and application thereof | 沈阳药科大学 | 2024-06-28 | — | — | CN | disclosed |
| EP-4384501-A1 | PROCESS FOR THE PREPARATION OF OLAPARIB, AND CRYSTALLINE FORM THEREOF | Glenmark Life Sciences Limited (IN) | 2024-06-19 | — | — | EP | disclosed |
| CN-117355303-A | Compounds and their use for the treatment of neurodegenerative, degenerative and metabolic disorders | 佛罗里达大学研究基金会公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117186045-A | Isobenzofuran-1 (3H) -ketone TREK-1 inhibitor, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2023-12-08 | — | — | CN | disclosed |
| CN-116535397-A | Isobenzofuran-1 (3H) -one compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2023-08-04 | — | — | CN | disclosed |
| CN-116143700-A | Phthalazinone compound, and preparation method and application thereof | 沈阳药科大学 | 2023-05-23 | — | — | CN | disclosed |
| WO-2023017393-A1 | PROCESS FOR THE PREPARATION OF OLAPARIB, AND CRYSTALLINE FORM THEREOF | GLENMARK LIFE SCIENCES LIMITED (IN) | 2023-02-16 | — | — | WO | disclosed |
| CN-106817899-B | Spiroheptane as ROCK inhibitor | 百时美施贵宝公司 | 2021-03-09 | — | — | CN | disclosed |