Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzoyl Peroxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoyl Peroxide SCHEMBL28829336 | 0.87 | LMNA (0.71) | PRMT1LMNAF2HTR6TSHR | |
| Benzoyl Peroxide SCHEMBL7768424 | 0.83 | LMNA (0.77) | LMNAF2CYP3A4TSHRKMT2A | |
| SCHEMBL163367 | 0.79 | HTR6 (0.80) | PRMT1LMNAHTR6CYP3A4CYP2C9 | |
| SCHEMBL11659821 | 0.79 | HTR6 (0.80) | PRMT1LMNAHTR6CYP3A4CYP2C9 | |
| Dapsone SCHEMBL27773927 | 0.79 | HTR6 (0.89) | PRMT1LMNAHTR6CYP3A4CYP2C9 | |
| Benzoyl Peroxide SCHEMBL28866244 | 0.77 | LMNA (0.74) | LMNAF2TSHRKMT2AALDH1A1 | |
| Benzoyl Peroxide SCHEMBL27660725 | 0.77 | LMNA (0.74) | LMNAF2TSHRKMT2AALDH1A1 | |
| Benzoyl Peroxide SCHEMBL28088599 | 0.77 | LMNA (0.74) | LMNAF2TSHRKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL10410274 | 0.77 | HTR6 (0.76) | PRMT1LMNAHTR6CYP3A4CYP2C9 | |
| (Phenylsulfonyl)Benzene SCHEMBL28511204 | 0.77 | HTR6 (0.75) | PRMT1LMNAHTR6CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110305747-A1 | COMBINATION OF DAPSONE WITH OTHER ANTI-ACNE AGENTS | ALLERGAN, INC. (US) | 2011-12-15 | — | — | US | disclosed |
| US-20110117182-A1 | COMBINATION OF DAPSONE WITH OTHER ANTI-ACNE AGENTS | ALLERGAN, INC. (US) | 2011-05-19 | — | — | US | disclosed |