Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PIR | O00625 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413200 | 0.85 | BRAF (0.49) | BRAFRIPK1BMPR1BPLK4PIR | |
| SCHEMBL413924 | 0.83 | IGF1R (0.55) | BRAFRIPK1KDRCDK8PAK1 | |
| SCHEMBL410366 | 0.83 | IGF1R (0.53) | BRAFRIPK1PAK1IGF1RNPC1 | |
| SCHEMBL416088 | 0.83 | BRAF (0.49) | BRAFRIPK1BMPR1BPLK4PIR | |
| SCHEMBL413702 | 0.81 | RIPK1 (0.52) | BRAFRIPK1RAF1KDRIGF1R | |
| SCHEMBL14620666 | 0.81 | IGF1R (0.44) | BRAFRIPK1PDGFRBPAK1CYP2C9 | |
| SCHEMBL410644 | 0.81 | KMT2A (0.52) | BRAFRIPK1PAK1IGF1RNHERF1 | |
| SCHEMBL415942 | 0.80 | RIPK1 (0.55) | BRAFRIPK1KDRCDK8CDK19 | |
| SCHEMBL413473 | 0.80 | BRD4 (0.46) | BRAFRIPK1BMPR1BPLK4PIR | |
| SCHEMBL414241 | 0.80 | ALDH1A1 (0.54) | BRAFRIPK1CSF1RIGF1RNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | BRAF 48/4885RIPK1 507/4885BMPR1B 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.