Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 2/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31237075 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1HPGDMAPTHSD11B1 | |
| SCHEMBL15301122 | 0.80 | HPGD (0.90) | SMN1; SMN2NPC1HPGDMAPTALDH1A1 | |
| SCHEMBL2646798 | 0.80 | HPGD (0.96) | SMN1; SMN2NPC1HPGDMAPTALDH1A1 | |
| SCHEMBL31335307 | 0.79 | HPGD (1.00) | SMN1; SMN2NPC1HPGDMAPTALDH1A1 | |
| SCHEMBL16416933 | 0.72 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1HTTLMNARAB9A | |
| SCHEMBL21409363 | 0.71 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1HPGDMAPTHSD11B1 | |
| SCHEMBL13858035 | 0.71 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1HPGDMAPTALDH1A1 | |
| SCHEMBL14617960 | 0.71 | ALDH1A1 (0.44) | ALDH1A1LMNAMEN1KMT2ACXCR3 | |
| SCHEMBL2376378 | 0.70 | SMN1; SMN2 (0.71) | SMN1; SMN2NPC1HPGDMAPTHSD11B1 | |
| SCHEMBL2798761 | 0.70 | L3MBTL1 (0.72) | SMN1; SMN2NPC1HPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-09-17 | — | — | US | disclosed |
| US-20180186771-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-07-05 | — | — | US | disclosed |
| US-9944620-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2018-04-17 | — | — | US | disclosed |
| EP-3024833-B1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2017-09-06 | — | — | EP | disclosed |
| US-20160176848-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186771-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IDO1, API5, IDO2 | SMN1; SMN2 4369/4885NPC1 4417/4885HPGD 567/4885 |
| US-10414754-B2 | Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them | IDO1, API5, IDO2 | SMN1; SMN2 4369/4885NPC1 4417/4885HPGD 567/4885 |
| US-20160176848-A1 | INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IDO1, API5, IDO2 | SMN1; SMN2 4369/4885NPC1 4417/4885HPGD 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.