Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.52 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.52 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838978 | 1.00 | MAPT (0.63) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL6400133 | 0.89 | MAPT (0.69) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL6398811 | 0.89 | MAPT (0.69) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL31373866 | 0.89 | MAPT (0.69) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL1153625 | 0.85 | HTT (0.60) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL4139305 | 0.84 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL9472620 | 0.84 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL5599045 | 0.84 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL4183115 | 0.84 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDGAAKMT2A | |
| SCHEMBL4139311 | 0.84 | ALDH1A1 (0.72) | MAPTALDH1A1HPGDGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237401-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | Pfizer Inc (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9738626-B2 | Antagonists of prostaglandin EP3 receptor | PFIZER INC. (US) | 2017-08-22 | — | — | US | disclosed |
| WO-2016103097-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2016-06-30 | — | — | WO | disclosed |
| US-20160176851-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PFIZER INC. (US) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176851-A1 | ANTAGONISTS OF PROSTAGLANDIN EP3 RECEPTOR | PTGER3, PTGES3, PTGER2 | MAPT 4882/4885ALDH1A1 2682/4885HPGD 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.