Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.80 |
| ▸ | TGFBR2 | P37173 | 8/20 | 0.80 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17840603 | 0.90 | TGFBR1 (0.64) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17863809 | 0.89 | TGFBR1 (0.65) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840684 | 0.89 | TGFBR1 (1.00) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840958 | 0.89 | TGFBR1 (0.86) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840768 | 0.86 | TGFBR1 (0.72) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840654 | 0.86 | TGFBR1 (0.80) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840626 | 0.85 | TGFBR1 (0.71) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840870 | 0.85 | TGFBR1 (0.70) | TGFBR1TGFBR2MAPK14PRKD1MAPK13 | |
| SCHEMBL17840735 | 0.81 | TGFBR1 (0.84) | TGFBR1TGFBR2RAF1DYRK1A | |
| SCHEMBL17840702 | 0.79 | TGFBR1 (0.78) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237415-A1 | TGF RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2017-11-01 | — | — | EP | disclosed |
| US-9708316-B2 | TGFβR antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708316-B2 | TGFβR antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| WO-2016106266-A1 | TGFβ RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016106266-A1 | TGFβ RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |
| US-20160176871-A1 | TGF BETA R ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2016-06-23 | — | — | US | disclosed |
| US-20160176871-A1 | TGF BETA R ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176871-A1 | TGF BETA R ANTAGONISTS | TGFBR2, TGFBR1, TGFB1 | TGFBR1 2/4885TGFBR2 1/4885MAPK14 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.