Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802496 | 0.85 | TRPA1 (0.37) | TRPA1TSHRL3MBTL1 | |
| SCHEMBL28844069 | 0.80 | TRPA1 (0.35) | TRPA1 | |
| SCHEMBL30020723 | 0.76 | PARP1 (0.34) | PARP1MAPTHSD17B10 | |
| SCHEMBL29638788 | 0.76 | TLR8 (0.43) | POLBMAPTTSHRHSD17B10 | |
| SCHEMBL28815824 | 0.76 | P2RX4 (0.37) | TRPA1MAPTTSHR | |
| SCHEMBL30007216 | 0.75 | TLR8 (0.38) | — | |
| SCHEMBL20425672 | 0.75 | TLR8 (0.40) | TRPA1NOS3NOS1NOS2 | |
| SCHEMBL17843467 | 0.74 | TP53 (0.49) | — | |
| SCHEMBL29638777 | 0.74 | TSHR (0.37) | TRPA1POLBMAPTTSHRL3MBTL1 | |
| SCHEMBL29638773 | 0.74 | TP53 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233835-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | claimed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | claimed |
| CN-117801107-A | Benzazepine derivatives, conjugates containing same and application thereof | 上海迪诺医药科技有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022242724-A1 | NITROGEN-CONTAINING COMPOUND, CONJUGATE CONTAINING SAID COMPOUND, AND APPLICATION THEREOF | 上海迪诺医药科技有限公司 | 2022-11-24 | — | — | WO | disclosed |
| CN-115317603-A | Antibody adjuvant conjugates | 小利兰·斯坦福大学托管委员会 | 2022-11-11 | — | — | CN | disclosed |
| CN-114585390-A | Aminobenzazepine compounds, immunoconjugates and uses thereof | 博尔特生物治疗药物有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-109843327-B | Antibody adjuvant conjugates | 小利兰·斯坦福大学托管委员会 | 2022-05-13 | — | — | CN | disclosed |
| EP-3233835-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |