Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA6 | P23280 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | TPMT | P51580 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622576 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL8890661 | 0.94 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL17844306 | 0.89 | NPC1 (0.59) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL8122418 | 0.86 | TSHR (0.78) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL8085474 | 0.86 | TSHR (0.78) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL7153812 | 0.86 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DCA12 | |
| SCHEMBL242563 | 0.85 | MRGPRX4 (0.77) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL21614005 | 0.85 | TSHR (0.76) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL5492174 | 0.85 | TSHR (0.76) | TSHRCA12CA1CA2CA4 | |
| SCHEMBL6583889 | 0.84 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233847-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex Suisse SA (CH) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016098005-A1 | AMIDO THIADIAZOLE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2016-06-23 | — | — | WO | disclosed |