Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318529 | 0.79 | NR3C2 (0.43) | KMT2ANR3C2ESR2MAPK1 | |
| SCHEMBL17847831 | 0.69 | CYP19A1 (0.46) | MEN1POLBKMT2ACYP19A1KDM4E | |
| SCHEMBL23355969 | 0.69 | KMT2A (0.45) | MEN1POLBKMT2ACYP19A1KDM4E | |
| SCHEMBL30951901 | 0.63 | CHRM2 (0.40) | MEN1POLBKMT2ACYP19A1CHRM2 | |
| SCHEMBL10444252 | 0.63 | KMT2A (0.38) | POLBKMT2ANR3C2MAPK1 | |
| SCHEMBL24418034 | 0.62 | HCAR2 (0.45) | MEN1POLBKMT2ACYP19A1ESR2 | |
| SCHEMBL5873337 | 0.62 | CES1 (0.39) | KMT2ANR3C2MAPK1 | |
| SCHEMBL2106697 | 0.62 | NR3C2 (0.38) | KMT2ANR3C2MAPK1 | |
| SCHEMBL8318293 | 0.60 | NR3C2 (0.38) | NR3C2MAPK1CHRM2 | |
| SCHEMBL27684711 | 0.60 | NR3C2 (0.40) | NR3C2ESR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233830-A1 | 1-METHYLPYRAZOLE-PIPERAZINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096126-A1 | 1-METHYLPYRAZOLE-PIPERAZINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2016-06-23 | — | — | WO | disclosed |