Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17844444 | 0.79 | MEN1 (0.38) | NR3C2MAPK1KMT2AESR2 | |
| SCHEMBL5873337 | 0.75 | CES1 (0.39) | NR3C2MAPK1ALDH1A1ALOX15CA1 | |
| SCHEMBL2106697 | 0.75 | NR3C2 (0.38) | NR3C2MAPK1ALDH1A1ALOX15CA1 | |
| SCHEMBL27684711 | 0.74 | NR3C2 (0.40) | NR3C2MAPK1ALDH1A1ALOX15CA1 | |
| SCHEMBL8318293 | 0.74 | NR3C2 (0.38) | NR3C2MAPK1CA1CA2CA5A | |
| SCHEMBL28947897 | 0.74 | NR3C2 (0.37) | NR3C2MAPK1ALDH1A1ALOX15CYP2C19 | |
| SCHEMBL10444252 | 0.72 | KMT2A (0.38) | NR3C2MAPK1ALDH1A1ALOX15MAPT | |
| SCHEMBL2105262 | 0.72 | NR3C2 (0.35) | NR3C2MAPK1ALDH1A1ALOX15CA1 | |
| SCHEMBL9114155 | 0.72 | MAPK1 (0.50) | MAPK1ALDH1A1ALOX15MAPTKMT2A | |
| SCHEMBL22892502 | 0.71 | NR3C2 (0.33) | NR3C2MAPK1CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929534-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013356-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-02 | — | — | WO | disclosed |