Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17838312 | 0.88 | CNR1 (0.43) | CNR1 | |
| SCHEMBL17844426 | 0.84 | KLKB1 (0.34) | NPC1CHRM4CHRM2CHRNA7P2RX7 | |
| SCHEMBL17844574 | 0.82 | CHRM4 (0.35) | CHRM4CHRM2KLKB1DGAT1 | |
| SCHEMBL16516469 | 0.77 | CFD (0.40) | NPC1CFDHTR3ACNR1CNR2 | |
| SCHEMBL23163208 | 0.75 | CFD (0.43) | NPC1CFD | |
| SCHEMBL30092705 | 0.74 | CFD (0.50) | NPC1CFDHTR3ACNR1CNR2 | |
| SCHEMBL16532464 | 0.73 | CFD (0.41) | NPC1CFDHTR3ACNR1CNR2 | |
| SCHEMBL17837846 | 0.73 | HPGD (0.40) | CNR1 | |
| SCHEMBL29900927 | 0.73 | CNR1 (0.43) | KLKB1CNR1 | |
| SCHEMBL20135491 | 0.72 | KLKB1 (0.33) | NPC1P2RX7KLKB1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233829-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | Pfizer Inc (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016097918-A1 | PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS | PFIZER INC. (US) | 2016-06-23 | — | — | WO | disclosed |