Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575887 | 0.84 | AKR1C3 (0.41) | TLK2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL13835304 | 0.77 | CA1 (0.35) | TLK2NPC1RAB9ACA1CA2 | |
| SCHEMBL20307667 | 0.77 | — | — | |
| SCHEMBL7504578 | 0.76 | CES2 (0.42) | TLK2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7504582 | 0.76 | CES2 (0.42) | TLK2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4057360 | 0.75 | — | — | |
| SCHEMBL10670137 | 0.74 | ALDH1A1 (0.37) | TLK2NPC1RAB9ACA1CA2 | |
| SCHEMBL12313017 | 0.73 | TLK2 (0.34) | TLK2NPC1RAB9ACA1CA2 | |
| SCHEMBL9112925 | 0.73 | — | — | |
| SCHEMBL9112918 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |