Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741031 | 0.86 | MAPT (0.39) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL27720282 | 0.86 | MAPT (0.39) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL17844812 | 0.83 | MAPT (0.37) | MAPTMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL28076433 | 0.82 | MAPT (0.46) | MAPTMEN1KMT2AHPGDALOX15 | |
| SCHEMBL17844814 | 0.82 | AOC3 (0.39) | MEN1KMT2AAOC3IDO1CYP2D6 | |
| SCHEMBL17844781 | 0.82 | AOC3 (0.39) | MEN1KMT2AAOC3IDO1CYP2D6 | |
| SCHEMBL27726392 | 0.80 | MAPT (0.44) | MAPTHPGDALOX15SLC6A2AOC3 | |
| SCHEMBL27747207 | 0.80 | MAPT (0.44) | MAPTHPGDALOX15SLC6A2AOC3 | |
| SCHEMBL27955103 | 0.80 | MAPT (0.44) | MAPTHPGDALOX15SLC6A2AOC3 | |
| SCHEMBL28625095 | 0.75 | MAPT (0.42) | MAPTHPGDALOX15SLC6A2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |